Category Archives: Stories of Hope

Stories

Pioneering breast cancer treatment

Breast cancer is the most common cancer among women and by funding breast cancer research, Al Jalila Foundation is enabling UAE-based scientist Dr Mawieh Hamad from University of Sharjah to ‘evaluate the anti-carcinogenic potential of biologically-driven intracellular iron depletion’ and discover improved treatment options for patients.

Breast cancer cells appear to exhibit increased levels of oxidative stress while iron chelation (removal of iron excess) has shown to minimise oxidative stress levels to where cell growth and division is reduced or stopped. However, iron chelation therapy carries toxic risks that potentially result in significant side-effects and even death. Other studies have suggested that estrogen treatment may also lead to intracellular iron depletion to minimise oxidative stress levels in cancer cells.

This study is examining the capacity of estrogen receptor (ER) engagement to induce cellular iron depletion and anti-growth effects in breast cancer cells.  The work has shown that ER signaling associates with significant labile iron pool (LIP) depletion resulting in reduced cell viability and proliferation with increased cell autophagy. This suggests the carcinogenic potential of ER signaling may exert significant anti-growth effects in cancer.  The study is currently in testing stages and data has already been presented in international scientific meetings and published in several international peer-reviewed journals.

Read more here about this promising research to give hope to breast cancer patients.

Ta’alouf empowers Kerolos to realise his potential

12-year-old Kerolos Mina Albert was born with Autism into a loving family who have always looked for ways to help him live a full life. Unfortunately, children with Autism often have difficulty expressing themselves which in turn makes it very challenging for parents to support them.

Kerolos’ mother, Youstina, had always been eager to learn as much of her son’s communication methods as possible and jumped on the opportunity to attend the Ta’alouf Parents Training program which empowers parents to give their children as much nurturing as they can. Since the training was held online it was very practical for his mother to attend the classes without having to leave home.

Ta’alouf program helped Kerolos’ mother meet her son’s needs: “I was feeling overwhelmed, but the Ta’alouf training was incredibly beneficial and gave me the confidence to focus on my son’s strengths. The trainers were extremely knowledgeable and approachable and really made me fully aware of the rights of people of determination and what services are available in the UAE. I would highly recommend this program to parents who have children of determination.”

These stories give us great joy and inspire us to continue our work to support children of determination and their families.

Youssef is blossoming with confidence

In November 2018 one-year-old Youssef was diagnosed with a right retinoblastoma, a rare form of eye cancer that had grown to a become a mass lesion in the right eye globe. The following month he underwent enucleation to remove the eye and the surgery was followed by chemotherapy treatment for 6 months.

As time passed, the doctors had recommended a prosthetic eye to be placed in the socket to assist with Youssef’s confidence as he grew older. Unfortunately, the cosmetic procedure was very expensive for Youssef’s parents to accommodate. They reached out for support and with the help of Al Jalila Foundation the case was presented to long standing partner Federal Authority for Government Human Resources (FAHR) who lead a company-wide fundraising campaign to raise the much needed funds to give Youssef, now three years old, a high-quality prosthetic eye.

Youssef’s mother was worried that he would have problems fitting in because of his condition: “As a mother, I was afraid that he may be bullied by children and we even avoided going out. Thanks to receiving the prosthetic eye, Youssef’s natural facial features have returned, and we are extremely grateful for all the support we received from Al Jalila Foundation.”

Today Youssef is a happy, confident young boy who enjoys playing with other children.

Kiehl’s employs creative art to make a difference

Kiehl’s, a leading cosmetics brand under L’Oréal, has been supporting Al Jalila Foundation every Ramadan since 2016 through their exclusive limited-edition collections featuring artwork from regionally celebrated artists and designers.

Launched in the Middle East less than a decade ago, we are delighted to see an international brand like Kiehl’s embrace the spirit of Ramadan whilst giving recognition to local talent and raising funds for a good cause.

The one-off designs have featured exceptional regional artists such as Fatma Al Mulla, Marwan Shakarchi, Ayah Tabari, Nourie Flayan and Eezmah. The artists have all expressed their enthusiasm for being selected as part of these charitable initiatives and are proud to display their cultural heritage and use their work to touch the lives of so many people in the UAE.

100% of proceeds from the sales of the designer products and gift boxes are dedicated to support a number of life-changing healthcare programs by Al Jalila Foundation. Through these Ramadan collaborations, Kiehl’s has donated almost USD 100,000.

We are grateful for organisations like Kiehl’s who use their creativity to engage the community to support a charitable cause. We cannot wait to see the next Kiehl’s Ramadan collection!

Principal is leading school to inclusion

Like many other adjustments that have been made in the world due to the COVID-19 pandemic, Al Jalila Foundation’s Ta’alouf Teachers Training program to empower students of determination has been conducted virtually since March 2020.

The school Principal, Mariyam Nizar Ahamed, and fellow teachers from Habitat School Al Tallah in Ajman, completed the online Ta’alouf program in June 2021 and are looking forward to implementing their new skills to support the students of determination in their school.

The online training has proven to be very insightful and beneficial for the teachers, parents and students alike. The newly launched online awareness sessions at Habitat School for all staff and parents has already been met with immense appreciation from parents who have found the practical and informative sessions invaluable. It has also helped to improve the relationship between teachers and parents.

Ms Mariyam believes that the training has been life-changing:  “As a result of this program, my team and I now have a clear path to implementing inclusion within the school and are applying the policies that have been laid out by the Ministry of Education. I would like to mention our heartfelt thanks to Al Jalila Foundation for improving the lives of students of determination.”

Treatment gives Mariam more days of joy

As a young mother, Mariam moved to the UAE with her husband and children to begin a new life. Three decades later and now retired, the couple love watching their grandchildren grow up close to them in the Emirates.

The COVID-19 pandemic had been difficult for many and particularly the elderly like Mariam and her husband who are at high risk. In April 2020, Mariam felt pain on her tongue but due to the fear of contracting the virus she hesitated to go to the doctor. However, after two months of being unable to eat or drink she visited the doctor and it was confirmed that she had a malignant cancerous tumour that needed to be removed right away.

The family were in shock and were at a loss for how they would financially manage to support Mariam’s treatment, as her husband’s health was also deteriorating and he needed an urgent heart operation.

The family found the support they desperately needed from Al Jalila Foundation and Mariam was able to undergo a successful operation removing the tumour completely. Today Mariam is in very good health and her family is grateful to have many more days to spend with their beloved mother and grandmother.

Finding therapies to manage colorectal cancer

Colorectal cancer (CRC) is the second most common cancer and the second highest cause of cancer deaths in the UAE.

To tackle the issue, Al Jalila Foundation awarded a research grant to Dr Maha Saber-Ayad, a medical Pharmacologist from the College of Medicine at University of Sharjah, to understand the role of galanin in CRC patients and potentially discover therapies that can prevent the progression of the disease.

The colon has a unique network of neurons that secrete various proteins known as “neuropeptides”, one of which is “galanin”.  The study evaluated the role of galanin in different stages of 80 CRC patients’ samples, using different lab techniques, including immunohistochemistry and next-generation sequencing, to take snapshots of the disease in different stages at the molecular level to decipher the role of the protein in the development of CRC.

Through bioinformatics analysis, several pathways were identified and implicated in tumour progression: cell cycle, cell division, autophagy (self-eating), regulation of expression of tumour suppressor genes, and immune system process.  Twelve key genes were shared among those pathways and in turn the expression of those genes evaluated in several CRC cell lines to validate results. These results can lead to the discovery of potential therapies and give hope to patients with CRC.

Scientist aims to give freedom to epilepsy patients

According to the World Health Organization epilepsy is one of the most common neurological diseases affecting people of all ages globally. It is estimated that up to 70% of people living with epilepsy could live seizure-free if properly diagnosed and treated.

Al Jalila Foundation research grant recipient Dr Hasan Mir from the American University of Sharjah is dedicated to developing a cost effective, more convenient, and accurate diagnosis that will enable improved treatment.

Treatment of epilepsy is facilitated by determining the brain location where a seizure originates. Computed tomography (CT) and magnetic resonance imaging (MRI) scans can be used to estimate this location but have the disadvantage of being specialised imaging modalities with limited availability and they are not suited to capturing transitory events, such as the seizure onset.

Dr Mir’s study investigates the use of electroencephalogram (EEG) source imaging as a cost-effective complement to an MRI in developing a high accuracy estimate of where the epileptic seizure location occurs on the brain.

The investigators have developed a real-time algorithm based on stochastic gradient descent to localise and track the space-time dynamics of brain sources. The efficacy of the proposed algorithm was verified for both simulated scenarios and clinical data. The team are currently working on further improvements to the algorithm along with a more comprehensive performance validation.

Mariam’s life-long dream is to help others heal

From a young age Mariam Elsaban had felt a strong desire to become a doctor because she wanted to help people and save lives. Her passion and dedication were only heightened throughout her school years and she took every opportunity to improve her knowledge and grades to give her the best chance to enter medical school.

In our mission to nurture the doctors of tomorrow, Al Jalila Foundation recognised Mariam’s talent and granted her a highly sought-after scholarship to pursue a Bachelor of Medicine, Bachelor of Surgery (MBBS) program at Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU).

“Receiving a scholarship from Al Jalila Foundation has been a life-altering experience and one I am immensely grateful for. It has paved the way for me to pursue my passion to help others through the art of healing.  Thanks to this opportunity I am in my fifth year of MBBS at MBRU and I find myself more eager than ever to use my skills as a physician to make a difference to patients’ lives.”

Mariam is well on her way to fulfilling her life-long dream of becoming a doctor and we look forward to seeing what she will achieve in the future.

Ali’s determination has no limits

8-year-old Ali was diagnosed with cerebral palsy as a toddler however the condition has not stopped him from being a superhero for other children of determination and an Ambassador of Hope for Al Jalila Foundation.

Ali’s mother heard about Heroes of Hope and the work they do to empower children of determination through sport and encouraged Ali to give it a try. From his first training in October 2020 Ali was hooked. He had been doing various physiotherapy which he found boring but as soon as he got into the gym, he loved it. After meeting Hollie, his coach, he set himself a challenge to show what children like him were capable of.

Ali recently completed a fitness challenge [1km rowing, 40 squats, 30 slam balls, 20 chin-ups and 100m prowler push] in an incredible time of 33 minutes to raise funds for Heroes of Hope in partnership with Al Jalila Foundation.

He loves training, his favourite activities are weightlifting and playing soccer, and he now dreams of becoming an Olympic champion – as a very focused and determined boy, he will surely get there!  Ali’s parents and his brother Omar are his greatest supporters and could not be prouder of him: “Ali’s determination to achieve something big gives him a lot of confidence and makes him proud of himself especially among his school peers. We know he can realise his dream of being in the Paralympics … the fitness challenge is just the beginning.”